self-heal

Prunella vulgaris

[category] flowers

[synonyms] xiju, Naidong (Ben Jing), Yanmian (BIE Lu), Prunella vulgaris, maixiaku, tiexianxiaku (Dian Nan Ben Cao), tiesecao (Gang Mu), bangzhutouhua (Chinese medicine Zhi Zhi), Dahua (Zhejiang traditional Chinese medicine manual), denglangtou, yangchangcai, langtoucao (Jiangsu Zhi Yao Zhi), baihuacao (Hebei herbal medicine), zhangsaticao (Shandong Zhong Zhi) The results showed that the total effective rates of the four herbs were as follows: Herba corallii, Herba dryleaf, Herba luochui, Herba Dongfeng, Herba niukui, Herba dikuniu, Herba Guanggu, Herba junyuegan, Herba bangtouzhu, Herba Mindong.

[source] it is the ear of Prunella vulgaris.

Prunella vulgaris

Perennial herbs. Stem square, base creeping, about 30 cm high, whole plant densely hairy. Leaves opposite; leaves petiolate near base, upper leaves sessile; leaves elliptic lanceolate, entire, or slightly serrate. Cymes terminal, spike shaped; bracts kidney shaped, base truncated or slightly heart-shaped, tip protruding into a long tail shape acuminate, back with coarse hair; calyx lip shaped, front with coarse hair, rear smooth, upper lip long elliptic, 3-lobed, both sides extended into semi lanceolate, lower lip 2-lobed, lobes triangular, apex acuminate; corolla purple or white, lip shaped, lower tubular, upper lip cap shaped Stamens 4,2-strong, filament tip bifurcated, one end with anther; ovary 4-lobed, style filiform. Nutlets brown, oblong, 3-ribbed. The flowering period is from May to June. The fruit period is from June to July.

It grows in wasteland, roadside and hillside grass. It is distributed in most parts of the country.

[collection] in summer, when the ear is half dry, it will be dried under the noise.

[medicinal materials] the dried fruit ears are long cylindrical or pagoda shaped, 2.5-6.5 cm long, 1-1.5 cm in diameter, brown or light purple brown, with persistent calyx in several to ten rounds, arranged in tile like arrangement. Each round has 5-6 persistent calyx with short stalk and 2 opposite bracts below. Bracts reniform, yellowish brown, longitudinal veins distinct, base cuneate, apex acutely caudate, abaxially with coarse white hairs, persistent calyx lip shaped, upper lip broad, apex 3-lobed, lower lip 2-lobed, lobes acutely triangular, outer hairy. The corolla and stamens have fallen off. There are 4 nutlets in the persistent calyx, brown and glossy. The body is light and crisp, with slight fragrance and light taste. Purple brown and big ear are the best.

It is mainly produced in Jiangsu, Anhui, Zhejiang, Henan and other provinces.

In Tibet and Yunnan, the flower and fruit ears of Prunella setosa are used as medicine.

[chemical constituents] the whole herb contains triterpenoid saponins. Its aglycone is oleanolic acid. It also contains free oleanolic acid, ursolic acid, rutin, Hyperoside, CIS caffeic acid, trans caffeic acid, vitamin B1, vitamin C, vitamin K, carotene, resin, bitterness, tannin, volatile oil, alkaloids, water-soluble salts (about 3.5%, of which about 63% is potassium chloride), etc.

The anthocyanins of delphinidin and cyanidin, d-camphor, d-anisone and ursolic acid were found in the spikes.

(1) antihypertensive effect

The water extract, ethanol water extract and 30% ethanol extract of Prunella vulgaris have the effect of reducing blood pressure in anesthetized animals. The decoction (100 mg / kg) injected into anesthetized dogs can produce significant and lasting antihypertensive effect, but it is easy to produce rapid tolerance, such as taking Prunella vulgaris to dogs with skin bridge. For renal hypertensive dogs, the blood pressure decreased moderately after 2 weeks of continuous administration, and returned to the original level after withdrawal. Prunella vulgaris stem, leaf, spike and the whole grass all had hypotensive effect, but the effect of spike was weak. After vagotomy, the hypotensive effect of Prunella vulgaris decreased significantly. It is suggested that the depressurization is not caused by the inhibition of the heart. The decoction can dilate blood vessels in the perfusion of Toad's lower limbs. When the dosage of total Acer free salt of Prunella vulgaris is equal to that of the decoction, there is no obvious antihypertensive effect. When the dosage of Prunella vulgaris is more than twice that of the decoction, the antihypertensive degree is only 1 / 4-1 / 6 of that of the decoction. Although the antihypertensive effect appears later, it lasts for a long time. Therefore, it is considered that the antihypertensive effect of Prunella vulgaris has nothing to do with the inorganic salt contained in it. In recent years, some people have repeatedly verified the above-mentioned experiments. It is found that the tincture (30% alcohol) of Prunella vulgaris stems and leaves contains a high potassium content, about 83 mEq / ml, and a small amount of potassium in the ear. Oral administration has no obvious antihypertensive effect on normal anesthetized dogs. After removing the inorganic salt, the antihypertensive effect of the decoction is very small, that is, intravenous injection of Prunella vulgaris has no antihypertensive effect on anesthetized animals In addition to the inorganic salt (mainly potassium), its antihypertensive components and antihypertensive mechanism need to be studied.

② Antibacterial action

According to the preliminary test in vitro, Prunella vulgaris decoction has inhibitory effect on Shigella dysentery, Salmonella typhi, Vibrio cholerae, Escherichia coli, proteus, Pseudomonas aeruginosa, Staphylococcus and Streptococcus, and has broad antibacterial spectrum. Its water extract (1:4) also has some inhibitory effect on some common pathogenic skin fungi in vitro. Prunella vulgaris can reduce the pathological changes of lung in mice with experimental tuberculosis.

③ Other functions

Prunella vulgaris Decoction (1:50-1:200) can make rabbit uterus appear tetanic contraction in vitro. High concentration can enhance peristalsis of isolated rabbit intestines. It has been reported that Prunella vulgaris decoction can inhibit the growth of s-160 tumor and Ehrlich ascites cancer in mice, but the death rate is higher than that in the control group, so it is a toxic effect.

Bitter, pungent and cold.

① Ben Jing: "bitter and pungent, cold. "

② Bielu: "non toxic. "

③ Ben Cao Zheng: "the taste is slightly bitter, slightly pungent. "

[Guijing] into the liver and gallbladder channels.

① "Into the liver. "

② "Entering the foot Jueyin and Shaoyang meridians" in the book of Materia Medica. "

Functions and indications: clearing liver and dispersing nodules. It is used to treat scrofula, gall, breast carbuncle, breast cancer, night pain of eyes, tears of shame, dizziness of head, askew of mouth and eye, pain of muscles and bones, tuberculosis, acute jaundice, infectious hepatitis, haemorrhage, leucorrhea.

(1) Qinggan Mingmu: used for liver heat, red swelling and pain, headache and dizziness of hyperactivity of liver Yang (such as hypertension). It can be mixed with Kudingcha and wild chrysanthemum.

(2) Qingre Sanjie: for mastitis, mumps, with bupleurum, red peony, Fritillaria thunbergii. For scrofula (such as lymph tuberculosis), gall (such as simple goiter), often with oyster, Fritillaria thunbergii.

① Ben Jing: "it is mainly used for cold and heat, scrofula, rat fistula, head sores, breaking through a hundred, dispersing galls and Qi, swelling and dampness of feet. "

② Supplement to the meaning of materia medica: "nourish the blood. "

③ "Diannan Materia Medica": "Dispelling liver wind, regulating meridians and collaterals, treating mouth and eye deviation. It can promote liver qi, open liver depression, stop pain in muscles and bones, eye pain, and disperse scrofula and tuberculosis all over the body. "

④ "Preparation of raw herbal medicine nature": "remove phlegm and pus, treat scrofula, clear upper and lower, remove eye mask and relieve pain. "

⑤ "Ben Cao Cong Xin": it is used to treat scrofula, rat fistula, gall, Baijian, mastitis and mastitis. "

⑥ "Scientific folk herbs": it has diuretic and bactericidal effects. Decoction can wash wound, treat suppurative external disease, wash vagina, treat vulva and uterine mucositis. "

⑦ Modern practical Chinese medicine: "it is a diuretic, effective for gonorrhea and uterine disease, and can treat hypertension and reduce blood pressure. "

[usage and dosage] oral administration: decoct soup, 2-5 yuan; boil cream or put into pill or powder. External use: fried, washed or tamped.

[should not] take it with caution if the spleen and stomach are weak.

① "Local melon is the best way to make it. "

② It is forbidden for those with Qi deficiency. "

[prescription selection] 1. For the treatment of scrofula, whether it has been broken or not, or it has been leaky for a long time: Prunella vulgaris, water for two minutes, fry it until seven minutes, remove the dross and take it far away. When the deficiency is serious, it should be taken with concentrated ointment and applied to the affected area. Taking more is good. Xiakucao Decoction

② Early treatment of mastitis: Prunella vulgaris, dandelion each equal. It can be taken by decocting with wine or making pills. (Ben Cao Hui Yan)

③ Treatment of liver deficiency, eye pain, cold tears more than, tendons pain, and eyes shy, afraid of the sun: Prunella half Liang, xiangfuzi one or two, a total of the end. Every time you take one money, you can adjust the wax tea. (brief prescription for all)

④ Treatment of blood collapse: Prunella vulgaris is the last. Take a square inch dagger and drink rice. (Sheng Hui Fang)

⑤ Under the rule of red and white belt: Prunella flowers, open when the harvest, dry at the end. Two yuan per serving, drink rice before eating. (compendium)

⑥ Treatment of postpartum hematuria, the desire to die: Prunella juice, take one. (compendium)

⑦ Cure mouth eye slant: Prunella a money, dannanxing five points, Fangfeng a money, fishing Uncaria a money. Fry in water, drink in water and take it when lying down. (materia medica of Southern Yunnan)

⑧ Cure head vertigo: Prunella (fresh) 2 liang, rock sugar 5 money. Stew in boiling water and take it after dinner. (Mindong materia medica)

⑨ Treatment of epilepsy, hypertension: Prunella (fresh) three Liang, winter honey one or two. Stew in boiling water. (Mindong materia medica)

⑩ Prevention of measles: Prunella five money to two Liang. Decoction, one dose a day, for three days. (Xuzhou, selection of new medical therapies based on single prescription)

(11) treatment of infantile bacillary dysentery: one or two Prunella vulgaris and five Scutellaria barbata for children under two years old; one or two Prunella vulgaris and one or two Scutellaria barbata for children between two and six years old; one or two Prunella vulgaris and one or two Scutellaria barbata for children between six and twelve years old. Take it in water. (selected works on infectious diseases)

(12) treatment of acute tonsillitis and sore throat: fresh Prunella vulgaris 2 to 3 Liang. Take it in water. (compendium of simple prescriptions of herbal medicine)

⒀ treatment of pemphigus: Smash Prunella vulgaris and add it to the material. (Yi Jian Fang for health)

(14) injury and knife injury. Chew Prunella in your mouth and apply it to the wound.

Sweating

Chinese PinYin : Xia Ku Cao