Tongguangsan

Tongguangsan

(selected Chinese herbal medicines in Yunnan)

[synonyms] milkvetch vine (Guizhou medicinal plant catalogue), Wuguteng, huangmuxiang, xianaiteng (Yunnan Chinese herbal medicine selection), Kuteng, diliquorice (Yunnan Simao Chinese herbal medicine selection), bianteng, laotengzi, baianxiao (Honghe Chinese herbal medicine selection).

[source] it is the vine, root or leaf of Tongguanteng, a plant of Asclepiadaceae.

[plant morphology] Tongguanteng

Deciduous climbing vines, 2-6 m long. The root is stout, woody, cylindrical, long and few branched, and the outer skin is gray brown. The upper part of the vine is oblate, pale green, and the lower part is deciduous yellow. Leaves opposite; heart-shaped, 8-14 cm long, 5-10 cm wide, apex pointed or pointed, entire or wavy, with yellowish or grayish white pubescence below; petiole 4-6 cm long. The flowers are small with red yellow petals. Follicles spindle shaped, growing in pairs, 5-9 cm long, densely covered with grayish yellow villi. The seeds have silky hairs. It blooms in summer.

It grows in the mixed forest on the sunny hillside or climbs on the rock wall. It is distributed in Yunnan.

[collection] the stems were collected in autumn and winter. Scrape off the embolus, slice and dry in the sun. The roots can be harvested all year round.

[chemical constituents] the stem contains bitter steroidal ester glycosides, and its main aglycone may be sarcocolonin.

[pharmacological action] 1. Effect on respiratory system

Guinea pigs had intraperitoneal injection of bitter steroidal glucoside (total glucoside, 100 mg / kg), which was isolated from rattan stem, which had a certain antiasthmatic effect (histamine spray). Intravenous injection of 60 mg / kg in rabbits could antagonize the lethal dose of histamine, but not in guinea pigs. The isolated guinea pig bronchial perfusion test showed that it could relax the tracheal spasm caused by histamine and weaken the contraction of isolated guinea pig intestinal tube caused by histamine. This product has no antitussive (ammonia induced cough) and expectorant (anesthetized dog) effects.

② Other functions

Intravenous injection of tongguangsan glucoside in anesthetized dogs has a short and mild hypotensive effect without rapid tolerance. It seems that its hypotensive effect has nothing to do with the central nervous system. The isolated rabbit heart showed no dilation effect. After intravenous injection, no damage to myocardium was observed by ECG. The antibacterial effect of 1% tongguangsan glucoside in vitro is poor, except for Pseudomonas aeruginosa, it has no effect on many other pathogenic bacteria. No poisoning or death was found in mice treated with 1500 mg / kg. The median lethal dose was 247 ± 28.61 mg / kg.

[nature and taste] 1. Selected Yunnan Chinese herbal medicines: "bitter, slightly cold. "

② "Red river Chinese herbal medicine": "bitter slightly sweet, cool. "

Functions and indications: clearing away heat and toxin, relieving cough and asthma. Treatment of pneumonia, bronchitis, bronchial asthma, pharyngitis, tonsillitis, cystitis, treatment of sore swelling poison.

① "Selection of Yunnan Chinese herbal medicine": "anti inflammation, cough, asthma, anti-cancer. Treatment of bronchitis, bronchial asthma, all kinds of cancer, rheumatism, falls, fractures, fundus diseases, stomach disease. "

② "Selection of Yunnan Simao Chinese herbal medicine": "clearing heat and detoxifying, anti-inflammatory and analgesic. Treatment of pharyngitis, gastrointestinal heat, pneumonia, tonsillitis, cystitis. "

③ "Guizhou medicine and plant catalog": "promoting blood circulation and muscle production, promoting lactation and relieving cough. Treatment of cough, falls, broken tendons, fractures, milk less. "

[usage and dosage] oral: decoction, 3-5 yuan. External use: tamping.

[selection] ① for laryngitis and oral ulceration: take Kuteng soaked in water. (selected Chinese herbal medicines from Simao, Yunnan)

② Treatment of gastroenteritis, stomachache, jaundice hepatitis: one or two roots of Platycodon. Take it in water. (Honghe Chinese herbal medicine)

③ Treatment of sore swelling: Tongguang powder fresh leaves appropriate. Smash the external application. (Yunnan economic plants)

④ Cure all kinds of cancer: Tong Guang San 12 to 125 money, white pepper 10. Take it by frying. (selected Chinese herbal medicines in Yunnan)

[clinical application] treatment of chronic tracheitis

Take tongguangsan 1-3 Liang, add 500 ml water, fry to 100-150 ml, take it three times a day, or make it into extract tablets, 0.5 g each, 3 times a day, 2-3 tablets each time. After a course of treatment (10 days), 75 cases were cured (28.8%), 80 cases were markedly effective (30.8%), 85 cases were improved (32.7%), and the total effective rate was 92.3%. Among them, 67 cases of asthmatic chronic tracheitis were treated with tablets. After 30 days of observation, the effective rate was 86%, the clinical control rate was 32%, and the effective rate was 31%. It is preliminarily considered that this product has good antiasthmatic and expectorant effects, but the anti-inflammatory effect is poor. Most of the symptoms disappeared or relieved after 7-10 days. There were no obvious side effects in the course of treatment, only some patients had dry mouth, dizziness, upper abdominal discomfort, nausea, very few drug rash, generally without treatment.

Chinese PinYin : Tong Guang San