Zhang can
Zhang can
Zhang can, female, was born in May 1965. Doctor, Professor, doctoral supervisor.
Character experience
He graduated from chemistry department of Nanjing University in 1986.
In 2000, he received a master's degree in pharmaceutical chemistry from China Pharmaceutical University.
In 2003, he received a doctorate in polymer chemistry and physics from Nanjing University.
In 2002, he went to Japan's Toyama Medical and Pharmaceutical University as a senior visiting scholar for further study.
In August 2006, he went to the University of Maryland for cooperation and exchange, and was employed as visiting professor by the University.
Lecture course
To undertake the teaching work of undergraduate course "medicinal polymer materials" and postgraduate course "selected treatises of pharmaceutical chemistry".
Research direction
1. Structural optimization of natural active compounds; 2. Macromolecular prodrugs; 3. Modification of natural polymers and their use as pharmaceutical carriers; 4. New drug nano preparations.
He has been engaged in the research of new pharmaceutical polymer materials and innovative drugs since his work. As the project leader, he has completed the National 863 project, the project of Jiangsu Economic and Trade Commission, the project of Jiangsu high tech, Jiangsu Natural Science Foundation, Jiangsu application foundation and other projects.
Main contributions
He is in charge of the National Natural Science Foundation of China, the key international exchange projects of the Ministry of science and technology, the key projects of the Ministry of education, the new century talent fund and the natural science foundation of Jiangsu Province. He has published more than 80 papers (more than 30 of which have been included in SCI), and has 10 patents (8 of which have been authorized).
Preside over the project
1. National Natural Science Foundation of China "Research on comb polymer materials used as pH sensitive and targeted drug carriers" (30772662), 2008.1-2010.12.
2. The new century talent fund (ncet-06-0499) presided over 500000 talents from January 2007 to December 2009.
3. Ministry of education key project "Research on chitosan phospholipid polymer lipid microparticle carrier" (107062) 3.2007.1-2009.12 presided over 100000.
(4) the major international exchange project of the Ministry of science and technology of the people's Republic of China "Research on the technology platform of o-sulfonic-n-octyl chitosan as the carrier of anti-tumor drugs" (2005 dfa30350) from August 2005 to August 2008 presided over 900000 projects.
5. Jiangsu Natural Science "Research on biomimetic pharmaceutical material phospholipid polymer liposome particles" (bk2006154) from July 2006 to December 2008, presided over 85000.
6. 863 project of the Ministry of science and technology of the people's Republic of China "development of o-sulfonic-n-octyl chitosan as a natural biodegradable pharmaceutical carrier material" (2004aa2z3232) from June 2004 to December 2005, presided over 800000 (accepted).
7. Jiangsu Provincial Natural Science Foundation (bk2001077) "Research on drug loading and targeting of chitosan derivative micelles as nano carriers of anti-tumor drugs" presided over 60000 (accepted) from August 2002 to October 2004.
8. Jiangsu Provincial Economic and Trade Commission project "Research on biodegradable pharmaceutical nano carrier materials" from August 2002 to October 2004, presided over 500000 (accepted).
9. Jiangsu Province high tech project (bg2002020) "modification of natural polymer and research as pharmaceutical carrier" from August 2002 to October 2004, presided over 200000 (accepted and passed the achievement appraisal).
Jiangsu Provincial innovation fund "development of a new class of excipients and paclitaxel micelles new preparation" presided over 950000 (completed) from September 2004 to December 2007.
(3) Jiangsu Provincial Economic and Trade Commission project "research and development of a new anti angina drug Renault Tai" from March 2005 to December 2007, presided over 100000 (completed).
academic achievements
⒈
CZhang
,GWQu,YJSun,XLWu,ZYao,QLGuo,QLDing,STYuan,ZLShen,QNPing, HPZhou.Pharmacokinetics ,biodistribution,efficacyandsafetyofN-octyl-O-sulphatechitosanmicellesloadedwithpaclitaxel.
Biomaterials
two thousand and eight
,
twenty-nine
:
one thousand two hundred and thirty-three
-1241
.(IF5.196）。
⒉
CZhang
,YCheng,GWQu,XLWu,YDing,ZHChen,LLYu, QNPing.PreparationandcharacterizationofgalactosylatedchitosancoatedBSAmicrospherescontaining5 -fluorouracil.
CarbohydratePolymers2008,72:390–397
(IF1.784）。
⒊
CZhang
,GWQu,YJSun,TYang,ZYao,WBShen,ZLShen,QLDing,HPZhou, QNPing.BiologicalEvaluationofN -octyl-O-sulfateChitosanasANewNano-CarrierofIntravenousDrugs.
EuropeanJournalofPharmaceuticalSciences2008,33:415–423
.(IF2.482）。
⒋XZhu,
CZhang
,XYTang,XLWu, QNPing.Preparation ,PhysicalPropertiesandStabilityofGambogicAcid-loadedMicellesBasedonChitosanDerivatives.
DrugdevelementandIndustialPharmacy2008,34
：
2-9
(IF0.821）。
⒌PZhang,HYe,TMin,
CZhang
.WaterSolublePoly(ethyleneglycol)Prodrug ofSilybin:Design ,Synthesis,andCharacterization.
JournalofAppliedPolymerScience2008
，
107:3230-3235
(IF1.306）。
⒍ZYao,
CZhang
,QNPing, LLYu.Aseriesofnovelchitosanderivatives :Synthesis,characterizationandmicellarsolubilizationofpaclitaxel.
CarbohydratePolymers2007,68:781–792
(IF1.784）。
⒎YXC,
CZhang
,WBShen,ZHChen,LLYu, QNPing.Poly (N-isopropylacrylamide）–chitosanasthermosensitiveinsitugel-formingsystemforoculardrugdelivery.
JournalofControlledRelease2007,120:186–194
(IF4.012）。
⒏
CZhang
,YDing,LLYu, QNPing.Polymericmicellesystemsofhydroxycamptothecinbasedonamphiphilicchitosanderivatives .
Colloidsand SurfacesB:Biointerfaces2007 ,55:192–199
.(IF1.789）。
⒐
CZhang
,QNPing,YDing, LLYu.NovelChitosan -DerivedNanomaterialsandTheirMicelle-FormingProperties.
Journalofagriculturalandfoodchemistry.2006,54:8409-8416
.(I
Chinese PinYin : Zhang Can
Zhang can
