Self deconvolution

Self deconvolution

(essential preparation of raw herbs)

[synonym] cross pearl grass (materia medica seeks the original), self ablation, tongxincao, dajinbuhuan (Lingnan medicine collection record), tongxinrong (Guangdong traditional Chinese Medicine).

[source] it is the stem and leaf of leguminous plant Eupatorium giganteum.

[plant morphology] big pig excrement bean, also known as wild lily.

Subshrub herb, 1-2 m high. The stems and branches are sericeous. Leaves simple, large, thin, oblong, sometimes oblanceolate, 5-12 cm long, 2-2.5 cm wide, apex with a small tip, base cuneate, bald above and silky pubescent below; stipules small, conic, persistent. Raceme is scattered, with 20-30 flowers, 30 cm long; bracteoles are 2, linear lanceolate; petiole is as long as calyx; calyx is 8-12 mm long, silky pilose; calyx tube is short, 5-lobed, cleft tooth lanceolate; corolla is butterfly shaped, golden yellow, 1.8 cm long, flag petal is round, wing petal is short, keel petal is as long as wing petal, extremely inward curved, beaked; stamen is 10, monosomic, anther is two-type; pistil is 2-shaped 1. Style long. Pods oblong, 4-5 cm long, bare, stipitate. The flowering period is from July to October. The fruit period is from August to November.

It is cultivated in the south of China. Distributed in Guangdong, Guangxi, Yunnan, Guizhou, Taiwan and other places.

The root of this plant (self dissipative root) is also used for medicine. Please refer to the special section for details.

[collection] harvest in summer and autumn.

The diameter of the dried branches is about 4-8 mm, with slightly raised longitudinal edges. The leaves are mostly broken, with grayish brown or grayish green on the top and gray on the back. The small stipules, yellow in color, are still visible on the branches, and they are attached to both sides of the petiole. The air is weak and the taste is light. It is better to have more leaves, complete and dry.

Produced in Guangdong.

[chemical constituents] it contains 2-3% monocrotaline.

[pharmacological action] 1. Anti tumor effect

Monocrotaline (see "wild lily" strip) has a significant inhibitory effect on the growth of sarcoma S-180, S-37 and lymphosarcoma No.1 ascites in mice. After various tests, it may be monocrotaline. It has obvious destructive effect on transplanted tumor cells in mice, and has obvious inhibition on mitosis or proliferation of tumor cells. The main reason is to destroy protein synthesis and metabolism of cells, so as to promote their degeneration.

② Liver damage and toxicity

The subacute toxicity of wild lily to dogs is mainly manifested as severe liver damage, non food intake and liver failure; the latent period of toxicity is long and often appears after drug withdrawal. The acute and subacute median lethal dose (LD50) in mice were 700 ± 57.3 mg / kg and 341.7 ± 17.8 mg / kg respectively. Various tests on mice and dogs showed that its main toxicity was liver damage, which was consistent with the nature of bifunctional pyrrolidine alkaloids.

[function indications] for cough, hematemesis, swelling, toothache, head sores in children.

① "Preparation of cattle herbal medicine": "treat swelling, apply big sores. "

② "Seeking the source of Materia Medica": "Xiaochuang Du is specially used to treat heaps of head sores in children. It can be decocted and washed with water, or used as the final oil. "

③ "For the treatment of toothache, take about ten pieces of its leaves, fry them together with a salted egg, add a little salt and drink them: apply them externally to reduce swelling."

④ "Raw herbal medicine manual": "treatment of heat cough, hematemesis, edema, yellow and thin skin color of children. "

[usage and dosage] oral administration: decoction. External use: tamping or grinding.

[clinical application] 1

Monocrotaline, an alkaloid isolated from the seed of Crotalaria macrophylla, has the same properties as that of nongjilin a (see "wild lily"). 26 cases of leukemia were treated. 2 cases got temporary remission, 4 cases got temporary remission, and 4 cases got progressive hemogram 8 cases. The total effective rate was 56%. Treatment: 100-200 mg daily, once or twice intravenous drip or intravenous injection, for about 2 weeks. If there is no progress in hemogram, monocrotaline should be stopped and other drugs should be used; if there is progress in hemogram, or if there is no obvious progress but the general condition is still good, medication can be continued. The longest medication time was 30 days, the total amount was 6.0 G. However, considering the toxicity of monocrotaline, it is suggested that the total course of treatment should not exceed 15 days and the total amount should not exceed 2.5G. According to the observation of this group of cases, the Hemogram of effective cases began to improve in 5-7 days after medication, and the most obvious improvement was in 12 days on average; but the effective period was relatively short, the shortest was only 3-5 days, and the longest was less than one month. Monocrotaline has toxic damage to liver, but individual differences are very large. The main manifestation of liver damage is the rise of serum alanine aminotransferase, which often appears 1-2 months after treatment. Severe liver damage can even cause death, so clinical application must be very careful!

② Treatment of malignant tumor

21 cases were treated with monocrotaline, including 4 cases of skin cancer, 3 cases of basal cell carcinoma, 4 cases of cervical cancer, 3 cases of malignant lymphoma, 4 cases of head and neck tumor, 1 case of esophageal cancer, 1 case of lung cancer and 1 case of mediastinal tumor. Results 2 cases were markedly effective and 1 case was effective. The standard of marked effect is that the symptoms are basically relieved or mostly relieved, and the tumor is reduced by more than half; the effective is that the symptoms are improved, and the tumor is reduced by less than half. Methods and dosage: 1. External powder, 15-80 mg / day, the minimum amount is 765 mg, the maximum amount is 1520 mg; 2. Local intratumoral injection, 30-100 mg / day, the minimum amount is 165 mg, the maximum amount is 2000 mg; 3. Intramuscular injection, 15-50 mg / day, the total amount is 600 mg; 4. Intravenous injection or drip, 100-200 mg / day, the total amount is about 3000 mg; 5 Intubation injection, most of 200 mg / day, the total amount is about 3000 mg. According to the different pathological changes, one or more of the above methods were used, and the course of treatment was generally 2-3 weeks. Toxicity: can affect liver, kidney and hematopoietic function; general side effects are nausea, vomiting, loss of appetite, weakness, dizziness, headache, etc.

Chinese PinYin : Zi Xiao Rong