Lu Daopei

Lu Daopei

Lu Daopei, male, Han nationality, born in Ningbo, Zhejiang Province on October 30, 1931, is a member of the agricultural and industrial Democratic Party of China, a member of the Communist Party of China, a hematologist and hematopoietic stem cell transplantation expert, an academician of the Chinese Academy of engineering, a member of the Academic Committee of the Department of medicine of Peking University, a chief expert of the State Key Discipline of Hematology of Peking University, and an honorary director of the Institute of Hematology of Peking University.

Lu Daopei graduated from Tongji Medical College in 1955, worked in Beijing Central People's Hospital from 1955 to 1958, served as deputy director and director of Peking University People's Hospital from 1959 to 2005, worked in blood laboratory of Peking University People's Hospital from 1962 to 2005, served as deputy chief physician of internal medicine of Peking University People's Hospital from 1978 to 1980, and went to the Royal Hospital of England in 1980 From 1981 to 2005, he served as director of the cell therapy center of Peking University People's Hospital; in 1986, he went to Harvard Medical School and Brigham women's hospital to specialize in leukemia and bone marrow transplantation; in 1993, he became a member of the Communist Party of China and the agricultural and industrial Democratic Party of China; in 1996, he was elected as an academician of the Chinese Academy of engineering; in 2005, he successively served as a doctor He served as director of Hematology center of the Fifth People's Hospital of Fudan University and chief physician of Peking University People's hospital.

Lu Daopei is mainly engaged in clinical and experimental research of blood diseases.

Character experience

Lu Daopei was born in October 1931 in Ningbo, Zhejiang Province. from September 1949 to May 1955, he studied medicine in Tongji Medical College and obtained a bachelor's degree after graduation. From January 1955 to January 1958, he worked in Beijing Central People's Hospital (now Peking University People's Hospital). From January 1959 to February 2005, he served as deputy director and director of Peking University People's hospital. from January 1962 to February 2005, he worked in the blood laboratory of people's Hospital of Peking University. from January 1978 to January 1980, he was the deputy chief physician of internal medicine in Peking University People's hospital. in 1980, he went to Hammersmith Hospital of the Royal College of physicians for further study. from January 1981 to February 2005, he was director of cell therapy center of Peking University People's hospital. In 1986, he went to Harvard Medical School and Brigham women's hospital to study leukemia and bone marrow transplantation. In January 1993, he became a member of the Communist Party of China and the Democratic Party of agriculture and industry. In 1996, he was elected academician of Chinese Academy of Engineering (Department of medicine and health). In January 2005, he served as director of Hematology center of the Fifth People's Hospital of Fudan University; in February 2005, he served as chief physician of Peking University People's hospital.

Main achievements

Achievements in scientific research

In the world, Lu Daopei first set a record of bone marrow from pregnant women; determined the minimum number of cells for bone marrow reconstruction; cured agammaglobulinemia with allogeneic bone marrow transplantation; used intravenous infusion of placental immunoglobulin to treat chronic graft-versus-host disease; used fetal liver and fetal thymus infusion to prevent graft-versus-host disease; and successfully transplanted allogeneic bone marrow injected via portal vein It is confirmed that the patients with drug-induced secondary aplastic anemia have obvious chromosome breakage, which provides important and direct evidence for the etiology of aplastic anemia. in Asia, Lu Daopei first solved the important obstacle of pulmonary embolism caused by fat and bone marrow particles in bone marrow transplantation, and successfully carried out allogeneic bone marrow transplantation (syngeneic) to cure severe aplastic anemia. in China, Lu Daopei first persistently transplanted live allogeneic bone marrow and allogeneic peripheral blood stem cells; first successfully carried out bone marrow transplantation for ABO major blood group incompatibility; first carried out t-cell-free bone marrow transplantation for matching incompatibility; found three kinds of genetic diseases; in the 1980s, he successfully returned the imported coagulation factor VIII without disinfection, avoiding the spread of AIDS in the north through blood products Beijing and China's domestic spread. In addition, Lu Daopei also systematically studied antithrombin kinetics and antithrombin III in the world, and proposed the calculation formula of prothrombin activity and antithrombin III; creatively summarized the calculation formula of leukemia cell nuclear area, and predicted the drug efficacy according to the change of cell nuclear area in early stage; used oral realgar to treat leukemia; proved that allicin was effective in vitro It can inhibit cytomegalovirus and identify the source of nucleated cells in recipients after allogeneic bone marrow transplantation by nuclear in situ hybridization. (1) in the early 1980s, when governments and pharmaceutical companies did not know or pay attention to the fact that blood products could infect AIDS, Lu Daopei insisted that Chinese foreign companies take back the unsterilized clotting factor VIII preparations, and reminded the Chinese pharmaceutical industry to avoid using most of the foreign blood products that might contaminate HIV, so as to avoid the spread of AIDS through blood friends It's widespread in China. (2) Lu Daopei found three kinds of hereditary diseases in China, including hereditary prothrombin deficiency and factor VIII deficiency in Chinese. (3) Lu Daopei put forward four innovative calculation formulas with practical value in the field of Hematology, two of which are related to coagulation: prothrombin activity and antithrombin III formula, and systematically studied the enzymatic kinetics of antithrombin III. (4) Lu Daopei first confirmed and reported that Arnebia extract has obvious therapeutic effect on phlebitis and vascular purpura at home and abroad. (1) in the international community, it is first confirmed that secondary aplastic anemia has chromosome damage. Therefore, Lu Daopei believes that the main cause of aplastic anemia is the defect of hematopoietic cells, rather than environmental factors such as immunity. In 1980 and 1981, Lu Daopei reported that he had successfully carried out allogeneic bone marrow transplantation for severe aplastic anemia. In 1961, he first proposed the treatment of aplastic anemia with testosterone and kidney tonifying herbs in China. Incidence rate incidence rate of Chinese aplastic anemia was 2. In 1960s, Lu Daopei first discovered that the incidence of aplastic anemia was closely related to the level of Chinese medicine. China's Deputy Minister of Health recommended that the production of the compound be stopped. The harm of the new reported anemia was reported in a timely manner. The incidence of secondary aplastic anemia in China was significantly reduced in 1960s. (3) Lu Daopei first introduced the formula of nuclear area change in leukemia and the formula of chromosome damage published by Wang Anqi. (4) in his book published in 1978, Lu Daopei reported that the remission rate of acute myeloid leukemia was 78% and that of acute lymphoblastic leukemia was more than 90%. (5) since the end of 1950s, Lu Daopei has only used realgar in the treatment of chronic myeloid leukemia. The main component of realgar is arsenic sulfide. Later, realgar was used in acute promyelocytic leukemia, which has significant curative effect. (6) in 1990, Lu Daopei first used PCR technology for prenatal diagnosis of fetal sex for eugenics detection of sex linked genetic diseases. according to the official website of the Chinese Academy of Engineering in June 2020, Lu Daopei has published more than 420 articles, including four monographs, including leukemia therapeutics. According to the official website of Tan Kah Kee Science Award Foundation in June 2020, Lu Daopei presided over three large and medium-sized international academic conferences and more than 10 national academic conferences. according to the official website of Chinese Academy of Engineering in June 2020, Lu Daopei has won the second prize of national science and technology progress award, the second prize of Chinese Medical Association Science and technology progress award, the first prize of Beijing Science and Technology Progress Award and other major awards, and the second prize of national medical book for leukemia therapeutics edited by Lu Daopei.

personnel training

According to the official website of Tan Kah Kee Science Award Foundation in June 2020, Lu Daopei trained 12 doctoral students and 11 master's students. Lu Daopei believes that life is not about greed, but about concentration. As an old saying goes, perseverance is the key to success. Today's young people always have the illusion that only old people have privileges in this world. In fact, it is not. Such privileges include the normal and orderly operation of human body functions and the persistent pursuit of the unknown. Lu Daopei believes that the pursuit of perfection is an enterprising attitude, not demanding perfection, nor compromising and perfunctory. Instead, he regards life as a process of dynamic growth. In the pursuit of perfection, only by tolerating imperfection can he live an open-minded and transparent life. Lu Daopei believes that people should always be grateful when they live a lifetime. Gratitude is not only a philosophy of life, but also a great wisdom in life. Sometimes, gratitude needs to be expressed in action and language, and only such gratitude can be two-way, flowing and feedback. As a medical student, it is important to always be grateful, but compared with pure spiritual gratitude, specific words and actual actions can make the grateful party understand this sincere feeling more deeply.

Honorary recognition

Social service

Personal life

At the end of October 1931, Lu Daopei was born in a family of several generations of doctors in Shanghai. He had seven brothers and sisters. Lu Daopei was the third. Although Lu Daopei's parents are busy with work, they are strict in educating their children. His parents were very generous in buying good books for them. As a child, Lu Daopei loved to buy and read books. When he was a child, he loved to read biographies of scientists. He was determined to take them as an example of his own struggle. When he grew up, Lu Daopei's extracurricular books included many books on psychology, logic and philosophy.

Character evaluation

Landway

Chinese PinYin : Lu Dao Pei