Li Cong

Li Cong

Li Cong, male, doctor, Professor, doctoral supervisor. Fudan University introduced talents. He received his doctorate from the University of Hong Kong in 2004. From 2005 to 2008, he worked as a postdoctoral in molecular imaging center of Department of Radiology, Johns Hopkins University School of medicine. From December 2008 to December 2008, he was an associate researcher, Professor, doctoral supervisor, vice president and director of the teaching and research section of Radiopharmacy in Fudan University School of pharmacy.

Educational experience

From April 2001 to October 2004, the Department of chemistry of the University of Hong Kong obtained a doctorate; from September 1997 to July 2000, the Department of chemistry of Wuhan University obtained a master's degree; from September 1993 to July 1997, the Department of chemistry of Wuhan University obtained a bachelor's degree

work experience

From December 2008 to December 2008, associate researcher, Professor, doctoral supervisor, School of pharmacy, Fudan University; from April 2005 to December 2008, Department of Radiology, Johns Hopkins University School of medicine, USA; postdoctoral; from October 2000 to February 2001, research assistant, Department of chemistry, University of Hong Kong

research field

Molecular imaging, pharmacology, tumor diagnosis and drug delivery.

Research direction

1. Glioma molecular probe 2. Molecular imaging study of tumor microenvironment 3. Image guided tumor immunotherapy

Category of experts

Professor, Ministry of education new century talent, Shanghai Education Commission dawn plan talent, Zhangjiang excellent talent

post

Deputy dean of School of pharmacy, Fudan University, director of Department of Radiopharmacy, doctoral supervisor

Scientific research achievements

The research work focuses on molecular imaging and molecular probes. In view of the clinical difficulties of glioma, such as "difficulty in accurate localization", "difficulty in complete resection", "difficulty in effective treatment", focusing on the key scientific issues of "spanning and regulating the blood-brain barrier of glioma", this paper focuses on the study of the structure and microenvironment characteristics of the blood-brain barrier in the infiltrating area of glioma, creates a secondary targeting strategy across the blood-brain barrier to trace the infiltrating area of glioma, and reveals the response signals of tumor microenvironment Objective to explore the feasibility of guiding the surgical resection of gliomas, and to establish a new method to actively target and regulate the blood-brain barrier permeability of gliomas. A series of achievements have been made in the key clinical fields of "precise positioning", "surgical navigation", "drug delivery" and "integration of diagnosis and treatment" of glioma. Presided over 4 projects of National Natural Science Foundation of China and 2 key projects of Shanghai Science and Technology Commission. Selected into the Ministry of education "new century talents", "Shanghai young scientific and technological talents", Shanghai Education Commission "dawn talents" and "Zhangjiang talents" program. In recent five years (since 2012), the corresponding author Adv.Mater .、ACSNano、 Chem.Sci .、Theranostics、Int.J.Cancer、J. Cereb.BloodFlow&Metab . and other mainstream journals published 21 SCI papers, total if151, average if7.4, cited more than 1000 times. Two patents have been authorized. The diagnosis of brain glioma across blood-brain barrier won the second prize of national science and Technology Progress Award in 2015 (ranking second). He also won the second prize of Shanghai Science and Technology Progress Award in 2014 (ranking fifth) and the first prize of science and technology progress award of Ministry of education in 2011 (ranking fifth).

Scientific research projects undertaken

The main research projects are as follows: NSFC general project, image guided function optimization of nano agonists to improve the neuroprotective effect of ischemic stroke, project leader, no.815717412016-2019; NSFC general project, targeted regulation of blood-brain barrier permeability to achieve image-guided brain tumor drug delivery, Project leader, no.813716242014-2017; general project of National Natural Science Foundation of China, tumor targeting "intelligent" near infrared fluorescent probe with pH stress ability, project leader, no.811713842012-2015; youth fund project of National Natural Science Foundation of China, collaborative therapy of siRNA gene interference and enzymatic hydrolysis prodrug cancer under the guidance of non-invasive medical imaging, Project leader, no.309003532010-2012; Ministry of education new century talents, molecular imaging and molecular probes, project leader, 2013-2015; Shanghai Municipal Science and Technology Commission basic research field experimental animal special project, establishment of non-invasive light transparent mouse dorsal skin window and its application in tumor microenvironment imaging, project leader, no.151409013002015-2017; Shanghai Municipal science and Technology Commission Basic Research Institute Project leader, no.12nm05014002012-2015, national major scientific research plan - Nano research project, research backbone, no.2013cb9325022013-2017, national major scientific research plan - protein research project, research backbone, no.2011cb910404021-2015

Social service

2016 to present member of glioma Committee of Chinese Medical Association 2015 to present member and Deputy Secretary General of biophoton Committee of Chinese society of Biomedical Engineering 2015 to present member of Shanghai Nuclear Society 2011 to present member of molecular imaging Committee of Chinese society of Biophysics

Awards and honors

The second prize of 2015 National Science and Technology Progress Award (the second complete adult); the second prize of 2014 Shanghai Science and Technology Progress Award (the fifth complete adult); the first prize of 2011 Ministry of Education Science and Technology Progress Award (the fifth complete adult)

representative work

1.XihuiGao,QiYue,ZiningLiu,MengjingKe,XingyuZhou,SihanLi,JianpingZhang,RenZhang,YingMaoandCongLi*,GuidingBrainTumorSurgeryviaBloodBrainBarrierPermeableGoldNanoprobeswithAcidTriggeredMRI/SERRSSignal, Adv.Mater .2017,Inpress. 2.QuJin,YuCai,SihanLi,HaoranLiu,XingyuZhou,ChunqiangLu,XihuiGao,JunQian,JunZhang,ShenghongJu*andCongLi*, Edaravone-EncapsulatedAgonisticMicellesSalvage/RescueIschemicBrainTissuebyTuningBlood-BrainBarrierPermeability,Theranostics,2017,7(4),884-898. 3.YunfeiZhang,HaoranLiu,JialiTang,ZhuoyunLi,XingyuZhou,RenZhang,LiangChen,YingMao*andCongLi*,NoninvasivelyImagingSubcutaneousTumorXenograftbyaHandheldRamanDetector,withtheAssistanceofanOpticalClearingAgent, ACSAppl.Mater.Interfaces ,2017,9(21),17769–17776. 4.JingyeZhang,ZiningLiu,PengLian,JunQian,XinweiLi,LuWang,WeiFu,LiangChen,XunbinWei*andCongLi*,SelectiveimagingandcancercelldeathviapHswitchablenear-infraredfluorescenceandphotothermaleffects, Chem.Sci .,2016,7,5995–6005. 5.ShuyanZheng,Ying-YingBai,YikangLiu,XihuiGao,YanLi,YinzhiChangyi, YuanchengWang,DiChang,ShenghongJu*andCongLi*,Salvagingbrainischemiabyincreasingneuroprotectantuptakeviananoagonistmediatedbloodbrainbarrierpermeabilityenhancement,Biomaterials,2015,66,9?20. 6.LuWan

Chinese PinYin : Li Cong