Kudigin

Kudigin

(records of traditional Chinese Medicine)

[synonym] digin (Liaoning commonly used Chinese herbal medicine manual), digongcao (plateau Chinese herbal medicine treatment manual).

[source] it is the whole plant of Corydalis viola.

[plant morphology] Corydalis glutinosa

Perennial herbs, 15-30 cm high. Stems from basal part of branches, glabrous. The basal leaf and the lower part of the stem are 3.5-10 cm long and long stalked; the leaf profile is ovate, 1.5-3.5 cm long, 3-4 pinnately divided, 1-2-3 pairs of lobes, obliquely broadly ovate, petiolate or almost sessile; the lobules are narrowly ovate to lanceolate, 0.5-1.2 mm wide. Raceme 1-6.5 cm long; bracts leafy; sepals small, 2-piece, sub triangular; corolla purple, petals 4,2-row, outer 2-petal large, lip shaped, front 1-petal flat, back 1-petal base spaced, inner 2-petal small, clawed, apex healed; stamens 6; ovary superior, style linear. Capsule narrowly elliptic, ca. 1. 6 cm long. The flowering period is April. The fruit period is from May to June.

It grows in gully, stream, plain, hilly grassland or under sparse forest. Distributed in Gansu, Shaanxi, Shanxi, Shandong, Hebei, Liaoning, Jilin, Heilongjiang, Sichuan and other places.

[collection] the whole grass was collected in summer, washed, dried and cut into sections.

[medicinal material] it is a dry shrunken whole grass, 5-10 cm long, with long petioles and three pinnate lobes. There are lilac flowers in the axils, or long oval flat pods with gray green surface and several oblate and black seeds. It tastes bitter.

[chemical constituents] it contains more than 10 kinds of alkaloids. Four different alkaloids were obtained from it, namely, a, B, C and D. It also contains coumarin lactones, steroidal saponins, phenolic substances, neutral resin and volatile oil.

[pharmacological action] the water extract (1:80) of human embryonic kidney primary monolayer epithelial cells can inhibit herpes simplex virus and delay the cytopathic effect of orphan virus. The main effective components of kudiging injection made from whole herb are alkaloids. It has antibacterial effect in vitro, and has inhibitory effect on Streptococcus A, pneumococcus, Catacoccus, dysentery bacillus, Escherichia coli and Pseudomonas aeruginosa (test tube method); it also has effect on Staphylococcus (golden and white) and octococcus (agar plate drilling method). In addition, the primary monolayer epithelial cells of human embryonic kidney were also cultured. 1:10 kuddin injection did not inhibit the poliomyelitis (vaccine strain) Aike 18, Coxsackie B1 and adenovirus type III. it did not inhibit the influenza A virus strain 68-1 (1:160) with four coagulation units, but inhibited the parainfluenza virus strain Sendai. The toxicity was very low. Mice were injected intraperitoneally about 120 times of human dose (8 ml / kg), but no death was found. When injected intraperitoneally with 10 ml / kg, 3 / 10 mice died. The blood pressure of anesthetized cats and dogs was decreased temporarily and recovered in half a minute by intravenous injection of kudiling injection. Perfusion of isolated frog heart could inhibit the heart.

[nature and taste] 1. The manual of commonly used Chinese herbal medicines in Liaoning Province: "bitter, pungent, cold. "

② "Plateau Chinese herbal medicine treatment manual": "cold nature, bitter taste, small poison. "

[Guijing] treatment manual of plateau Chinese herbal medicine: "entering heart and spleen meridians. "

[function indications] clearing away heat and toxin. It is used to treat febrile diseases, high fever, irritability, influenza, infectious hepatitis, nephritis, parotitis, sore and other suppurative infections.

① "Liaoning commonly used Chinese herbal medicine manual": "heat clearing and detoxification. Treatment of carbuncle, gangrene, swelling, lymph node tuberculosis. "

② Hebei Handbook of traditional Chinese medicine: "treating acute infectious hepatitis. "

③ "Plateau Chinese herbal medicine treatment manual": "anti inflammation and detoxification. Treatment of jaundice, hepatitis, high fever, irritability. "

[usage and dosage] oral administration: decoction, 1-3 yuan (fresh 1-2 Liang); or mashed juice. External use: tamping.

[selection] ① treatment of acute infectious hepatitis: one or two dices, decoction. (Hebei Traditional Chinese medicine manual)

② Treatment of dysentery: Herba digiti with clematis, Sanguisorba officinalis, decoction service. (manual of plateau Chinese herbal medicine treatment)

③ Treatment of finger infection at the beginning, lymphangitis (red silk) swelling heat pain: indigo, wild chrysanthemum each one or two. Take it in water. (Hebei Traditional Chinese medicine manual)

④ Treatment of emphysema: fresh diced, scallion, raw honey tamping. (Handbook of commonly used Chinese herbal medicines in Liaoning)

⑤ Treatment of damp heat sores: Diding one or two, honeysuckle one or two, dandelion one or two, Folium Isatidis three money. Take it in water. (Handbook of commonly used Chinese herbal medicines in Liaoning)

[clinical application] treatment of infectious diseases

Use green or yellow green kudigin with pod to make injection, every 2 ml is equivalent to 2 g crude drug. 2-4 ml intramuscular injection each time, children's discretion, twice a day, or increase or decrease according to the condition. 297 cases of influenza, upper respiratory tract infection, bronchitis, bronchopneumonia, tonsillitis, acute nephritis, acute and chronic pyelonephritis were treated. 184 cases (62.3%) were cured, 70 cases (23.3%) were effective, and 43 cases (14.4%) were ineffective.

Chinese PinYin : Ku Di Ding