Psoralea corylifolia

Chinese Name: Psoralea corylifolia

[category] Fructus Psoraleae

[synonyms] Hu Jiuzi (Xu Biao's nanzhouji), Po Guzhi, rag paper (theory of medicinal properties), bu Gu Ling (Ben Cao Tu Jing), Heiguzi, Hu GuZi (records of traditional Chinese Medicine), Ji GuZi (Jiangxi traditional Chinese Medicine).

[source] it is the fruit of Psoralea corylifolia.

[plant morphology] Psoralea corylifolia

Annual herb, 40-90 cm high, covered with yellowish white hairs and dark brown glandular dots. Stem erect, branches hard, with longitudinal edges. The leaves are alternate, with one lateral leaflet at the end of the branch; the leaves are broad ovate or triangular ovate, 4-11 cm long and 3-8 cm wide, the apex is round or obtuse, the base is heart-shaped, oblique heart-shaped or round, the edge has broad teeth, and there are obvious black glandular spots on both sides of the leaves; the petiole is 2-4 cm long, and the petiole is 2-3 mm long, covered with white villi; the stipules are in pairs, triangular lanceolate, about 1 cm long, membranous Quality. Flowers numerous, densely in panicle like racemes; rachis axillary, about 6-10 cm long; calyx campanulate, base connected into a tube, apex 5-toothed, covered with black glandular dots; corolla butterfly shaped, lavender or yellow, flag petal oblong ovate, wing petal broad linear, keel petal oblong, apex obtuse, slightly curved; stamens 10, 1 bundle, anther small; pistil 1, ovary superior, obovate or linear, style filiform. The pods are oval, with persistent calyx, black pericarp, attached to the seeds; the seeds are 1, fragrant and fishy. The flowering period is from July to August. The fruit period is from September to October.

Cultivated or wild. Distributed in Henan, Anhui, Guangdong, Shaanxi, Shanxi, Jiangxi, Sichuan, Yunnan, Guizhou and other places.

[collection] when the fruit matures in autumn, take the ear, dry it in the sun, lay down the fruit and remove impurities.

[herbal medicine] the dried fruit is oblate or slightly kidney shaped, 3-5 mm long, 2-4 mm in diameter, 1.5 mm thick, slightly concave in the center, dark brown on the surface, rough, with fine reticular wrinkles and dense glandular spots, and a few fruits have light gray brown persistent calyx outside. The pericarp is thin and hard to separate from the seed coat. There is one kernel with two cotyledons, light brown to light yellow brown, rich in oil. It is slightly fragrant and bitter. The seeds are big and black. Plump, solid and free of impurities is preferred.

It is mainly produced in Sichuan, Henan, Shaanxi, Anhui and other places.

[chemical constituents] the fruit contains about 20% volatile oil, organic acid, a methyl glucoside, alkali soluble resin, nonvolatile terpenoid oil and saponin. The seed contains about 1.1% coumarin psoralen and isopsoralen, flavonoid psoralen flavone, methyl psoralen flavone, isopsoralen flavone and chalcone, isopsoralen chalcone, monoterpenol derivative psoralen, volatile oil, resin and fatty oil. The flower contains fatty oil, volatile oil, sterol, alkaloid and so on. This plant also contains raffinose.

[pharmacological action] ① effect on cardiovascular system

Psoralen B, one of the fruits of Psoralea corylifolia, can dilate the coronary arteries of isolated hearts of guinea pigs, rabbits, cats and rats. Its effect is four times stronger than that of Kailin, and it can resist the vasoconstrictive effect of pituitrin on the coronary arteries. However, it has little effect on the total peripheral vascular resistance, indicating that it has a high selectivity in dilating the coronary arteries. Psoralen derivatives can increase the blood flow of coronary artery and peripheral vessels in dogs. Psoralen B can also enhance the cardiac contractility of guinea pigs and rats, excite frog heart, and resist the heart failure caused by lactic acid. The increase of respiratory quotient has little effect on myocardial oxidative phosphorylation, glycogen and lactic acid, so it does not promote myocardial anaerobic metabolism. The toxicity of slow administration is very low.

② Antibacterial action

In addition, it has antibacterial effect on Staphylococcus aureus, as well as the extract of Fructus Psoraleae. The petroleum ether extract of seeds has inhibitory effect on earthworm, so it may have the effect of anthelmintic.

③ Psoralen crude extract can treat vitiligo and psoriasis, and can be used locally and orally. It is known that psoralen is the effective component of psoralen, which has little toxicity and needs a large dose to form teratogenesis (rat and guinea pig experiments). The extract from the seeds of P. Leguminosea has photosensitizing effect on rabbits and can treat vitiligo.

④ The effect on smooth muscle

Psoralea corylifolia seed extract has excitatory effect on isolated and in situ intestines, but relaxant effect on isolated guinea pig uterus.

⑤ Estrogen like effect

When female rats (ovariectomized rats and normal rats) were given 0.35 g or 0.175 g of Psoralea seed powder (mixed with diet) every day, it could increase vaginal keratosis, and the effect was reversible. 0.25 g of Psoralea seed powder could open the vagina of immature female rats, and the estrogen like effect was very weak, but psoralen had no such effect. Feeding 0.35 g of Psoralea seed powder for 37-77 days could damage the fertility of adult female rats, but the change was positive It can be recovered after a week of regular diet, but it has no effect on male rats fed for 46 days.

[processing] Psoralea corylifolia: remove impurities, wash and dry in the sun. Salt Psoralea corylifolia: take Psoralea corylifolia, mix well with salt water, moisten slightly, put it in a pot, stir fry it with slow fire until it bulges slightly, take it out and dry it in the air. (100 Jin per Psoralea corylifolia. Use 2 jin 8 liang of salt, add proper amount of boiling water to make it clear)

① "Lei Gong Paozhi Lun" says: "all Psoralea corylifolia is soaked in wine for one night and then dries out, but it is soaked in Dongliu water for three days and nights. From now on to Shenchu, it is dried every day. "

② "Rihuazi Materia Medica": "Psoralea corylifolia is used as a medicine to stir fry. "

[flavor] pungent, warm.

① "Lei Gong Paozhi Lun": "sex poison. "

② "On medicinal properties": "bitter and pungent in taste. "

③ Kaibao materia medica: "it is pungent, warm and nontoxic. "

④ Modern practical Chinese medicine: "it tastes hard and sweet. "

[Guijing] into the kidney meridian.

① "Into the kidney meridian. "

② In the book of Materia Medica Huiyan, "we should start with Jueyin, zutaiyin and Mingmen. "

③ "Ben Cao Jing Jie": "enter the stomach meridian of Foot Yangming, lung meridian of hand Taiyin, kidney meridian of foot Shaoyin. "

④ Summary of materia medica: "entering the foot Shaoyin and Jueyin meridians. "

[function indications] tonifying kidney and Yang. It can treat kidney deficiency, cold diarrhea, enuresis, spermatorrhea, frequent urination, impotence, low back and knee cold pain, deficiency cold asthma and cough. External treatment of vitiligo.

① According to the theory of medicinal properties, "the main man has low back pain, cold knee and wet bladder, stubborn cold arthralgia, convenient stopping small and cold abdomen. "

② "Rihuazi Materia Medica" says: "Invigorating Yang affairs, treating cold labor, and making eyes and ears clear. "

③ "Kaibao Materia Medica" says: "it is mainly composed of five labors and seven injuries, wind deficiency and cold, bone marrow injury and failure, cold kidney, seminal fluid and blood gas abortion. "

④ The essence of pinhui: "strengthen the essence. "

⑤ "Compendium": "treat kidney discharge, pass life gate, warm elixir field, collect spirit. "

⑥ Yuluo Yaojie: "warm the soil and water, digest the diet, ascend the spleen and stomach, restrain the symptoms of slippery discharge, spermatorrhea, purgation, excessive drowning and slippery stool. "

⑦ Yilin zuanyao: "treating deficiency cold, asthma and cough. "

[usage and dosage] oral administration: decoction, 1.5-3 yuan; or into pills, powder. External use: grind and rub or dip in wine.

[should avoid] those with Yin deficiency and excessive fire should not take it.

① Haiyao materia medica: "evil licorice. "

② The Compendium: "avoid blood, get walnuts and walnuts. "

③ According to the classic of Materia Medica, "it is not suitable for those who suffer from Yin deficiency, fire, dreaminess, blood in urine, short and astringent urine, red day, bitter mouth and dry tongue, dry stool, thirst due to internal heat, red eyes due to fire, easily hungry and noisy, flaccid due to dampness and heat, and bone weakness. "

④ "Depai Materia Medica": "it is forbidden to use Yin deficiency, depression, internal heat, thirst, dizziness, Qi deficiency, pregnant heart cell heat, and constipation. "

[prescription selection] ① Treat Spleen and kidney weakness, do not eat: four liang of old paper (fried incense), two liang of nutmeg . For the fine, forty-nine big fat dates, ginger 42, slices cooked together, jujube rotten to ginger, peel dates and peel the core and meat, paste for research, medicine and pestle, pills such as Wutong Zi. Take 30 pills each time, add salt to the soup. (ER Shen Wan in Ben Shi Fang)

② Treatment of red and white dysentery and watery diarrhea: one or two pieces of old-fashioned paper (fried and cooked), four or two pieces of poppy shell (remove the root and tip, dry on the new tile). On the two flavor, for the fine end, refining honey for the ball, such as marble big. Take one pill each time, one cup of water to boil, two pieces of ginger and one jujube, and decoct them for seven points. For children, take four. (Bai Yi Xuan Fang)

③ Treatment of infantile enuresis: one or two pieces of old paper (fried). At the end of the day, each serving one money, hot soup tune down. (on Buyao pocket formula for children)

④ For men and women, five labors and seven injuries, long cold in the lower Yuan Dynasty, black moustache and temples, all kinds of wind diseases, limb pain, standing face and Strengthening Qi: a kilogram of Psoralea corylifolia, soaked in wine for a night, put it dry, but use a liter of black oil hemp and stir fry it, so that the sound of the hemp is absolutely tossed away, only take Psoralea corylifolia as the end, vinegar boiled noodles paste pills as big as Wuzi. In the morning, warm wine, salt soup under 20 pills. (behind the experience)

⑤ Under the rule, Yuan Xu was defeated, his feet and hands were heavy, and he sweated at night. This medicine can strengthen the muscles and bones and improve the vitality: four liang of Psoralea corylifolia (stir fried), four liang of Cuscuta chinensis (steamed with wine), one or two of walnut (peeled), three and a half yuan of frankincense, myrrh and aloes (each research). Honey balls are as big as Wuzi. Take 20 or 30 pills each time. Take hollow salt soup and warm wine every day from summer solstice to winter solstice. (kufang Buguzhi pill)

⑥ Set the heart, tonify the kidney: two pieces of old-fashioned paper (fried with paper to make it fragrant), one or two pieces of white Poria Cocos (peeled). The last two flavors are fine Wutong, with half of the myrrh, beat and break, soak in soot free wine, and high myrrh, and then wait for two thick flavors. Take three or fifty pills each time, and take the soup with you. If you don't have the medicine of ZAONAN pills, take the pills with less wine paste before eating. (Huijing pill in Wei's family collection)

⑦ Treatment of kidney qi deficiency cold, excessive urination: old paper (salt fried), fennel (salt fried). The best is divided into fine ends, and the wine paste is large as Wutong. Each take 50 pills or 100 pills, hollow warm wine, salt soup. (the family of Wei)

Chinese PinYin : Bu Gu Zhi