LU Hong

LU Hong

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LU Hong: Professor and doctoral supervisor of Institute of genetics, School of life sciences, Fudan University from 2006 to now; associate professor and master supervisor of Institute of genetics, School of life sciences, Fudan University from 2001 to 2006; Postdoctoral Fellow of Institute of genetics, School of life sciences, Fudan University from 1999 to 2001; Postdoctoral Fellow of Academy of life sciences, Nanjing University from 1997 to 1999; PhD degree in biology, Russian Academy of Sciences from 1997.

Profile

Date of birth: 1965

Title: Professor, doctoral supervisor

Research direction

Basic research of microbial molecular genetics and applied basic research of microbial genetic engineering

Epigenetics

A study of

Why are there phenotypic differences between identical twins with the same genome sequence? Many diseases (such as tumors) have no mutation in gene sequences. Why do gene expression patterns change? In order to solve the mystery of life and explore the essence of the occurrence and development of major diseases, we mainly use yeast as a model organism, and also use mammalian cell model to study the establishment, recognition, and response network of nucleosome histone post-translational modification (nucleosome histone code), reveal the basic rules of precise regulation of gene expression, and answer the basic questions in epigenetic regulation The basic scientific problems provide new ideas and theoretical models for disease early warning, diagnosis, and intervention treatment of epigenetic regulatory network.

Exploitation and utilization of gene resources of special environment microorganism

Only 1% of the microorganisms in the environment can be cultivated, and less than 0.1% in the special environment can be cultivated. In order to excavate the gene resources of uncultivated microorganisms for the benefit of human beings, we mainly carried out the following three aspects: 1) to excavate the gene resources of Chinese Yak rumen microorganisms as a breakthrough, establish a high-throughput technology platform for functional screening, and at present focus on screening, cloning and identifying a number of enzyme genes related to cellulose degradation; 2) to utilize genetic engineering and structural analysis In order to improve the enzymatic properties of cellulose degrading enzymes from natural sources, bioinformatics and other disciplines should be used to study the structure and function of proteins. 3) To construct and transform various unconventional yeast expression systems (e.g. Kluyveromyces chickpea expression system, Pichia pastoris expression system, etc.) and obtain various types of yeast expression systems (secretory expression, intracellular expression, constitutive expression, induced expression, etc.) to meet the expression needs of different types of foreign proteins; at the same time, to study the expression rules of foreign genes and realize in yeast expression High level expression in the system, to obtain high-yield yeast genetic engineering strains to meet the application needs.

The research team sincerely invites hardworking and ambitious people, especially postdoctoral researchers, to join us.

research project

Completed research projects

There is one major scientific and technological project of Shanghai biomedicine, one sub project of the national key scientific and technological project of the tenth five year plan, one National Natural Science Foundation of China and two China Postdoctoral fund.

Research projects under research

973 project, 2009 cb825601, regulation and function of histone modification, 2009.01-2013.08

2. NSFC general project, 30771145, yeast as model organism, research on the code of nucleosome histone H4 in DNA damage response, 2008.01-2010.12

3. NSFC general project, 30671175, the mechanism of orphan receptor of nuclear hormone regulating gene transcription, 2007.01-2009.12

4. Doctoral program foundation of the Ministry of education, 20060246017, research on the mechanism of nuclear hormone orphan receptor regulating apolipoprotein apocIII gene expression, 2007.1-2009.12

5.863 key project, 2007aa021302, high throughput gene isolation technology for special microbial resources, 2007.6-2010.12

6. Cooperative project: high expression of alkaline mannanase, 863 key project, Institute of Microbiology, Chinese Academy of Sciences, 2007.6-2010.12

7. Cooperation project: Research on the prototype drug of long-acting TNF  soluble receptor, Shanghai key, Renji Hospital Affiliated to Medical College of Jiaotong University, 2006.7.1-2009.7.30

8. Cooperation project: key technology and product development of Jerusalem artichoke biorefinery, third phase of knowledge innovation project of Chinese Academy of Sciences, cooperation with Dalian Institute of chemistry, October 2006 to October 2009

9. Horizontal project: Research on genetically engineered yeast producing feed enzyme, Wuhan xinhuayang Biotechnology Co., Ltd., may 2007-May 2010

Representative papers

(* contact author)

1.WeiCao,ShuaiTang,HanyingYuan,HonghaiWang,XinZhao,HongLu*AMycobacteriumtuberculosisantigenWag31inducesexpressionofaC-chemokine,XCL2,inmacrophagesCurrentMicrobiology2008Jul11， PMID:18618175

2.WeiCao,NansongLiu,ShuaiTang,LeiBao,LiShen,HanyingYuan,YuyangLi,XinZhao,HongLu*Acetyl-CoenzymeAacyltransferase2attenuatestheapoptoticeffectsofBNIP3intwohumancelllinesBBA-GeneralSubject1780(6):873-880,2008

3.JiadongWang,NansongLiu,ZhongleLiu,YangLi,ChiSong,HanyingYuan,Yu-yangLi,XinZhaoandHongLu*.TheorphannuclearreceptorRev-erbβrecruitsTip60andHDAC1toregulateApolip oproteinCIIIPromoter.BBA -MolecularCellResearch2007BiochimicaetBiophysicaActa(BBA)-MolecularCellResearch1783(2):224-236，February2008

4.JiadongWang,YangLi,MinZhang,ZhongleLiu,CongWu,HanyingYuan,Yu-YangLi,XinZhao,HongLu*.AzincfingerHITdomain-containingprotein,ZNHIT-1,interactswithorphannuclearhormonereceptorRev-erbβandremovesRev-erbβ-inducedinhibitionofapoCIIItranscriptionTheFEBSJournal274:5370-5381,2007

The inactivation of recombinant psy5 gene by Pichia pastoris was reduced. Journal of Fudan University (NATURAL SCIENCE EDITION) 47 (3): 311-3172008

6.FuGu,ChunYou,AoChen,YaoYu,JianpingLiu,XiangWang,XiaoyiSheng,Yu-YangLiandHongLu*Genecloning,expressionandpurificationanovelhumantissue-specificDNApolymeraseλ2.ScienceinChinaSeriesCLifeSciences（SCICHINASERC）Vol50（4）：457-465，2007

7.Jian-PingLiu,Nan-SongLiu,Han-YingYuan,QianGuo,HongLu*,Yu- YangLi.HumanHomologueofSetaBindingProtein1InteractswithCathepsinBandParticipatesinTNF -InducedApoptosis inOvarianCancerCells.MolecularandCellularBiochemistry ,Volum

Chinese PinYin : Lv Hong