Hedyotis diffusa

[Chinese name] < U > Tongcao < / u > (records of Guangxi Traditional Chinese Medicine)

[category]

[synonym] Hedyotis diffusa, Hedyotis breviflora (Guangxi Traditional Chinese medicine annals), Hedyotis diffusa (Minnan folk herbal medicine), momushengcao, jiejieruicao (Quanzhou herbal medicine), wengeli, qiandachao, yangxucao (Guangdong traditional Chinese Medicine II), Hedyotis diffusa, Salix tenuifolia (Fujian traditional Chinese Medicine).

[source] Hedyotis diffusa with roots.

[plant morphology] Hedyotis diffusa, also known as Humulus bicolor.

Annual herb, 15-50 cm high. Cilium slightly weak, terete or glabrous, glabrous. Leaves opposite, petiolate or sessile; leaf blade linear to linear lanceolate, 1-3.5 cm long, 1-3 mm wide, leathery; stipules membranous, base united into sheath, 1-2 mm long, apex denticulate. Flowers solitary or 2 in leaf axils, sessile or nearly sessile; calyx tubular, 4-lobed, lobes margin with short bristles; corolla funnel-shaped, ca. 3 mm long. Pure white, apex 4-lobed, glabrous; stamen 4; ovary 2-locular, stigma 2-lobed, hemispherical. Capsule, oblate, 2-3 mm in diam., locular dorsum dehiscent, calyx persistent. The seeds are brownish yellow and very small. The flowering period is from July to September. The fruit period is from August to October.

It grows on the hillside, roadside and riverside grass. Distributed in Yunnan, Guangdong, Guangxi, Fujian, Zhejiang, Jiangsu, Anhui and other places.

[collection] harvest in summer and autumn, dry or fresh.

It has a main root, about 2-4 mm thick. The fibrous root is thin and light gray brown. The stem is thin and curly, brittle and easy to break, with white pith in the center. The leaves are mostly broken, extremely shrunken and easy to fall off; stipules 1-2 mm long. Flowers axillary. The air is weak and the taste is light.

Mainly produced in Fujian, Guangdong, Guangxi and other places.

In Fujian and Guangxi, the same genus of plants, such as Clematis (see "Clematis", "Cordyceps", "Cordyceps", "Cordyceps" and so on, are also used as Hedyotis diffusa.

[chemical constituents] TRIACONTANE, stigmasterol, ursolic acid, oleanolic acid, β - sitosterol, β - sitosterol-d-glucoside and p-coumaric acid were isolated from the whole plant.

[pharmacological action] 1. Anti tumor effect

In vitro (equivalent to 6 g / ml crude drug) has a strong inhibitory effect on acute lymphocytic type, granulocytic type, monocyte type and chronic granulocytic type tumor cells (methylene blue test tube method); the inhibitory effect on the former two types of tumor cells is also strong when measured with Warner respirator. The extract has been used in the treatment of S-180 and Ehrlich ascites carcinoma in mice and Yoshida sarcoma in rats, but it has no obvious anticancer effect. 0.5-1 g / ml crude drug can inhibit Yoshida sarcoma and Ehrlich ascites carcinoma in vitro (methylene blue test tube method), but the author thinks that it is nonspecific.

② Antibacterial and anti-inflammatory effects

The antibacterial effect in vitro was not significant, but only weak to Staphylococcus aureus and Shigella. To observe the effect of Decoction on the phagocytic function of reticuloendothelial system and phagocytic activity of leukocytes in normal and artificial appendicitis rabbits, it is considered that its anti-inflammatory effect is caused by stimulating the proliferation of reticuloendothelial system and enhancing the phagocytic activity.

Bitter and sweet, cold.

① "Western traditional Chinese medicine annals": "bitter sweet, warm, non-toxic. ""

② "Minnan folk herbal medicine": "bitter, flat, non-toxic. ""

③ "Quanzhou Materia Medica": "sweet acid, cold nature. ""

④ "Guangdong traditional Chinese medicine" II: "pungent, cold, non-toxic. ""

[Guijing] records of Guangxi Traditional Chinese medicine: entering the heart, liver and spleen. ""

Functions and indications: clearing away heat, removing dampness and detoxifying. Treatment of lung heat, asthma, cough, tonsillitis. Pharyngitis, appendicitis, dysentery, urinary tract infection, jaundice, hepatitis, pelvic inflammatory disease, adnexitis, carbuncle, sore, snake bite, tumor. It can also be used for digestive tract cancer.

① "Chaozhou Zhi. Wuchanzhi": "the stem and leaf juice drink, the treatment of appendicitis, but also can treat all intestinal diseases. ""

② "Records of Guangxi Traditional Chinese medicine": "treatment of infantile malnutrition, snakebite, cancer. External treatment of white blister sores, snake scabies. ""

③ "Minnan folk herbal medicine": "heat clearing and detoxification, anti-inflammatory and analgesic. ""

④ "Quanzhou Materia Medica": "clearing heat, dispersing blood stasis, removing carbuncle and detoxifying. It is used to treat carbuncle, sore and rash. It can also clear lung fire and diarrhea lung heat. Treatment of lung heat and asthma, cough against chest tightness. ""

⑤ Guangxi Chinese herbal medicine: clearing away heat and toxin, promoting blood circulation and diuresis. Treatment of tonsillitis, pharyngitis, appendicitis, hepatitis, dysentery, urinary tract infection, infantile malnutrition. ""

[usage and dosage] oral administration: decoction, 1-2 Liang; or mash juice. External use: tamping.

[taboo] Guangxi records of traditional Chinese medicine: "pregnant women should be cautious. ""

[prescription selection] ① for dysentery and urethritis: Hedyotis diffusa L. Take it in water. (Fujian Chinese herbal medicine)

② Treatment of jaundice: Hedyotis diffusa 1-22. Take the juice and kimono. (Xiamen)

③ Treatment of acute appendicitis: Hedyotis diffusa two to four Liang, one to two liang, root three money. Take it in water. (selected Chinese herbal medicine prescriptions, Guangdong)

④ Treatment of children's fever, can't sleep: a spoonful of fresh snake tongue juice. (Minnan folk herbal medicine)

⑤ Treatment of sore swelling, heat and pain: wash the fresh snake tongue, mash and apply it, and replace it when it is dry. (Minnan folk herbal medicine)

⑥ Treatment of snakebite: fresh Hedyotis diffusa 1 to 2 liang. Mash the juice or fry it in water, and apply the residue to the wound. (Fujian Chinese herbal medicine)

[clinical application] 1

Two milliliters of Hedyotis diffusa injection (containing 4 grams of active ingredients) were injected intramuscularly for 5-7 days. 112 cases were cured in 52 cases, nearly cured in 25 cases, improved in 17 cases, ineffective in 12 cases, and died in 6 cases. The average hospital stay was 7.98 days

② Treatment of appendicitis

Take fresh Hedyotis diffusa 1 Liang (dry product 5 yuan), decoction, twice a day. Children should be reduced. The number of severe cases increased to 2-3 Liang. Some patients with severe abdominal distension were treated with water or new acupuncture, while those with severe poisoning symptoms were treated with rehydration and fasting. 19 cases were cured, including 12 cases of acute appendicitis and 3 cases of appendiceal abscess. The treatment lasted for 8-9 days, with an average of 1.9 days and 3.3 days. The symptoms and signs disappeared in 3.2 days and 6 days. One case recurred after 4 months and was still cured by the same method. It has been reported that 4 liang of fresh whole grass (1-2 liang of dry products) were used for decocting 1-2 doses a day, or 100% injection was made for intramuscular injection, 2 ml each time, twice a day, once every 6 hours in severe cases. More than 50 cases of various types of appendicitis (including acute, subacute and appendiceal perforation complicated with peritonitis) were treated. Generally, the clinical symptoms disappeared after 2-3 days of medication, and were cured and discharged in 1 week. Among them, the curative effect of acute appendicitis is the best. The curative effect of decoction is better than that of injection. In addition, 30 cases of acute and chronic appendicitis were treated with Decoction orally. Hedyotis diffusa was used only for simple appendicitis, mild appendicitis and patients admitted to hospital within 1-2 days after onset. For severe appendicitis patients with obvious systemic and local symptoms, haijinsha, yequancao or other drugs were used. Except for 2 cases of chronic appendicitis who were re admitted to hospital for surgical treatment, they were all cured. The average hospital stay was 4.2 days.

③ Treatment of epididymis after vasectomy

On the basis of commonly used spermatic cord block and traditional Chinese and Western medicine treatment, Hedyotis diffusa (decocted 12 times a day, generally 3-4 weeks as a course of treatment, the longest taking more than 10 weeks) can improve the curative effect, especially for simple epididymis. Among them, 6 cases had vasectomy, 1 case had epididymis resection, 2 cases had painful nodule resection, and the results were not ideal. After the application of Hedyotis diffusa, the main symptoms of 3 cases of 10 cases of simple stasis disappeared basically, the epididymis became soft, and the tenderness of epididymis was alleviated or disappeared; the symptoms of 7 cases were improved, and the tenderness of epididymis was alleviated; among 9 cases with inflammation of spermatic cord and epididymis, 6 cases were improved, and 3 cases were ineffective. It is considered that Hedyotis diffusa has the effect of inhibiting spermatogenesis, alleviating epididymis stasis and eliminating inflammation, so it can receive the therapeutic effect. But for the cases of adhesion of spermatic cord and granuloma formation of epididymis, the curative effect is not good.

④ Treatment of snakebite

Take 5 yuan of the product, boil Baijiu for 3~5 minutes, remove the residue, take 2 / 3 oral (1 days and 2~3 times), 1 / 3 external application. When applying the medicine, first suck out the poisonous blood from the wound, clean and disinfect it, then cover it with a sterile cotton pad, and then wet the dressing with medicinal wine (to keep it moist). If you can not drink, you can boil it with water, then add some Baijiu after boiling, but still generally boil baijiu. Other Chinese herbal medicines and antibiotics should be added to the patients with persistent edema, serious condition and wound infection; for the mild and medium-sized cases, only this method can be used. According to the observation of 19 cases, they were cured after 3-6 doses of medication.

⑤ Treatment of pelvic inflammatory disease, appendicitis

Use 1.5 liang of Hedyotis diffusa, add 3 yuan of Jinniu (Zanthoxylum nitidum), or add 3 yuan of Changzhi (Ganoderma lucidum), decoct in water, 1 dose daily. After treatment, 4 cases were invalid and the rest were cured.

In addition, 100% Hedyotis diffusa injection was injected intramuscularly, 2 ml each time, three times a day, for the treatment of cervical cancer, gastric cancer, gastric cancer

Chinese PinYin : Bai Hua She She Cao