Xie Xiaoliang

Xie Xiaoliang

Xiaoliang sunney Xie, born in Beijing, China in 1962, is a biophysical chemist. He is an academician of the National Academy of Sciences, the National Academy of medicine, the American Academy of Arts and Sciences, and a foreign academician of the Chinese Academy of Sciences. He was a tenured professor of the Department of chemistry and chemical biology of Harvard University, a lecture professor of Mallinckrodt, and a director of the Department of science of Peking University Professor Xi, director of the biomedical frontier innovation center of Peking University, and director of the future gene diagnosis innovation center of Peking University.

In 1980, he was admitted to the Department of chemistry of Peking University. He graduated from University of California at San Diego in 1990 and entered postdoctoral research in University of Chicago. In 1992, he entered the PNNL work in the Pacific Northwest. He was the first scientist to come from Chinese mainland since the establishment of PNNL in 1965. He was appointed professor of lifelong chemistry and chemical biology in 1999. The first Chinese mainland lifelong professor introduced after the opening of the Harvard University, Professor Mallinckrodt, Professor of the Harvard University in 2009, is the first person to get the title of Professor Harvard University after the reform and opening up. In 2010, he founded the Peking University biological dynamic optical imaging center as the director. In 2016, he set up the future of genetic diagnosis. He was elected as a foreign academician of the Chinese Academy of Sciences in 2017 and returned to Peking University full-time in July 2018.

Xie Xiaoliang's main research directions include basic research, technology development and medical research. Basic research: single molecule enzymology, single molecule biophysical chemistry, gene expression and regulation, epigenetics, mechanism of cell differentiation and reprogramming, genomic instability; technology development: single molecule imaging, single cell genomics, coherent Raman scattering microscopy, DNA sequencing; medical research: in vitro fertilization embryo preimplantation genetic screening and diagnosis, early cancer diagnosis Break.

Character experience

Xie Xiaoliang was born in Beijing in June 1962, and spent his primary and secondary school years in the primary school affiliated to Peking University and the secondary school affiliated to Peking University.

In 1980, he was admitted to the Department of chemistry of Peking University. In his spare time, he also attended the courses of the Department of physics and mathematics. During the summer vacation, he went to the laboratory to do experiments, learn organic synthesis, and write computer programs to do chemical calculations.

In the summer of 1985, he went to the University of California, San Diego to study for a Ph.D. under the guidance of John Simon, who studies ultrafast laser and chemical kinetics.

In 1989, after graduation, he went to the laboratory of Graham Fleming, a professor of physical chemistry at the University of Chicago to be a postdoctoral.

In 1992, he entered the PNNL, and was engaged in the research of single molecular spectroscopy and dynamics, and super high resolution optical imaging. It is the first scientist in Chinese mainland since PNNL was founded in 1965.

In 1999, he was appointed professor of life in the Department of chemistry and chemical biology, Harvard University. He was the first professor in Chinese mainland since the reform and opening up.

In 2000, in his first year at Harvard University, Xie Xiaoliang wrote six applications, all of which were funded.

On July, 2001, he was appointed as a visiting professor of the State Key Laboratory of molecular dynamics, Beijing University.

In 2004, he won the National Institutes of Health (NIH) Pioneer Award, and in the next five years, he received US $500000 in discretionary funds each year.

In 2008, he was employed as a chair professor by school of life sciences, Peking University.

In 2009, he served as the chair professor of Mallinckrodt at Harvard University. He was the first mainland scholar to win the title of chair professor at Harvard University after the reform and opening up.

In December 2010, he presided over and founded the biological dynamic optical imaging center (biopic) of Peking University as the director.

In 2013, he won the National Institutes of Health (NIH) Pioneer Award for the second time.

In 2015, Xie Xiaoliang and Professor Karl deisseroth of Stanford University jointly won the Albany biomedical award, becoming the first Chinese winner of the award, and won the Debye award of the American Chemical Society in the same year.

In 2016, the Beijing future gene diagnosis Innovation Center (ICG) was established as the director, and was elected as the academician of the National Academy of Medicine on October 17.

On September 16, 2017, he won the Qiushi outstanding scientist Award; in November, he was elected as a foreign academician of the Chinese Academy of Sciences.

In July 2018, he formally returned to Peking University full-time to work as Professor Li Zhaoji of Peking University; in the same year, he served as the director of the biological dynamic optical imaging center of Peking University, which was renamed as "biomedical pioneer Innovation Center (biopic) of Peking University".

In November 2019, he served as the director of Science Department of Peking University.

Main achievements

Achievements in scientific research

Xie Xiaoliang is the founder of single molecule enzymology, one of the founders of single molecule biophysical chemistry, and the pioneer of coherent Raman scattering microscopy and single cell genomics. As a single molecule biophysical chemist, Professor Xie Xiaoliang has the courage to break through the discipline boundaries, from physical chemistry, biophysics to biochemistry, and then to molecular biology, genomics and clinical medicine. He is fearless to explore and constantly innovate, and has made innovative contributions in related emerging interdisciplinary.

Xie Xiaoliang is not only an international leader in the basic research of biophysical chemistry, but also vigorously promotes the application of label free optical imaging technology and new single cell genome sequencing technology in medicine in recent years. In 2012, Xie Xiaoliang made a breakthrough in the research of single-cell whole genome, and developed a new method of single-cell whole genome uniform amplification multiple annealing cycle amplification (malbac). On September 19, 2014, the world's first "malbac baby" was born in Beijing Third Hospital, marking that China's preimplantation genetic diagnosis technology is at the world's leading level. So far, using malbac technology, Xie Xiaoliang's team has successfully avoided the offspring transmission of the disease for more than 300 families with monogenic genetic diseases in China, avoided the transfer of chromosomal abnormal embryos for thousands of pregnant women, and reduced the incidence of abortion, Down's syndrome and other chromosomal abnormal diseases.

The research direction of Xie Xiaoliang's research group includes three fields: basic science research field, technology research field and medical research field.

fundamental research

: single molecule enzymology, single molecule biophysical chemistry, gene expression and regulation, epigenetics, mechanism of cell differentiation and reprogramming, genomic instability;

technological development

Methods: single molecule imaging, single cell genomics, coherent Raman scattering microscopy, DNA sequencing;

Medical research

Objective: in vitro fertilization, preimplantation genetic screening and diagnosis, early cancer diagnosis.

As of April 2017, Professor Xie Xiaoliang has published more than 210 SCI indexed scientific papers.

SingleMoleculeSpectroscopyandImaging

Xie,X.Sunney;Dunn,RobertC."ProbingSingleMoleculeDynamics"Science265:361-364(1994).

Sánchez,ErikJ;Novotny,Lukas;Xie,X.Sunney."Near-fieldFluorescenceMicroscopyBasedonTwo-photonExcitationwithMetalTips"PhysRevLett82:4014-4017(1999).

Min,Wei;Lu,Sijia;Chong,Shasha;Roy,Rahul;Holtom,GaryR.;Xie,X.Sunney."ImagingChromophoreswithUndetectableFluorescencebyStimulatedEmissionMicroscopy"Nature461:1105-1109(2009).

Chong,Shasha;Min,Wei;Xie,X.Sunney."Ground-StateDepletionM icroscopy:DetectionSensitivityofSingle-MoleculeOpticalAbsorptionatRoomTemperature "JPhysChemLett1:3316-3322(2010).

Zhou,Yuexin;Wang,Ping;Tang,Feng;Gao,Ge;Huang,Lei;Wei,Wensheng;Xie,X.Sunney“Paintingaspecificchrom

Chinese PinYin : Xie Xiao Liang