Wang Wen
Wang Wen
Wang Wen, male, Ph.D., researcher, doctoral supervisor, assistant director of Kunming Institute of zoology, Chinese Academy of Sciences, winner of outstanding young scholars, winner of 100 Talents Program, expert of national 10 million talents project, expert enjoying special government allowance, leader of evolutionary genomics group of young scientists from China, Germany and Mapu, executive deputy director of Key Laboratory of cell and molecular evolution.
He once served as deputy director of Kunming Institute of zoology, Chinese Academy of Sciences and Secretary of Discipline Inspection Commission.
Biography of characters
He graduated from Department of biology, Wuhan University in 1989 with a bachelor's degree;
In 1992, under the guidance of the late academician Shi liming, he obtained a master's degree in Kunming Institute of zoology, Chinese Academy of Sciences;
He was a visiting scholar at Columbia University from October 1995 to June 1996;
In 1996, under the guidance of Prof. Shi Liming and Prof. Wu Heling, he obtained his doctorate in Kunming Institute of zoology;
From August 1997 to July 2002, he worked as a research assistant and postdoctoral researcher in the Department of ecology and advanced chemistry, University of Chicago, USA;
In 2004, he won the outstanding youth talent fund of NSFC;
In 2004, it was selected as one of the first batch of "ten million talents project";
In 2005, he was deputy director of Kunming Institute of zoology, Chinese Academy of Sciences.
academic research
Research direction
1. Heredity, development and evolution are important problems in life science. Traditional evolutionary developmental biology (Evo devo) is to explore the ancient and common development mechanism of animals, many views and hypotheses are difficult to be verified and explained at the level of species differentiation. Recently, the new development of Evo devo mainly focuses on the regulation of intraspecific or interspecific genes. However, our recent studies on the origin and evolution of new genes and their functions show that the emergence of a new gene can have an important impact on phenotype or development process. We plan to use new genes related to animal development and evolution as models to reveal the mechanism of origin, evolution and maintenance adjustment of new pathways, and explore a new way to unify cognitive genetics, development and evolution.
2. The mechanism of artificial selection and genome evolution. Domestic animals and cultivated crops are the important material basis for the existence and development of human civilization and society. However, since Darwin first systematically discussed the phenomenon of significant variation of domestic animals and cultivated plants due to artificial selection, due to the complexity of artificial breeding traits and the fact that they often do not follow the typical Mendelian mode of inheritance, people still know little about the genetic mechanism of artificial selection and the changes and evolutionary rules of genes and genomes under artificial selection We don't know much about the mechanism of natural selection. With the accumulation of genomic data and the rapid development of evolutionary genomics theory and technology, we have been able to systematically study the genetic mechanism of artificial selection at the large-scale level of genome. This project aims to define a large number of genes and genome regions affected by artificial selection, and summarize the genetic mechanism and general rules of artificial selection through large-scale comparative analysis of domesticated organisms and their wild species at the level of genome and epigenomics. Using large-scale transgenic technology, a number of important genes related to artificial selection traits were identified, which provided important theoretical guidance and gene and strain resources for genetic and genetic engineering breeding.
3. Other evolutionary genomics research topics, such as the origin and evolution of animal toxin genes, the evolution of new sex chromosomes, the evolution of new exons and so on.
research subject
1. In cooperation with Professor Long Manyuan's laboratory at the University of Chicago, we plan to screen Drosophila melanogaster and its 8 related species by fluorescence in situ hybridization (FISH) using the cDNA of about 6000 Drosophila melanogaster (about 13600 Drosophila melanogaster genes). After screening candidate genes, referring to the idea of studying Sphinx gene, the structure, function, origin and molecular evolution pattern of new genes were analyzed by Southern hybridization, gene library screening, race, RT-PCR and genomic dnapcr, and the most general rules of new gene generation were summarized and inferred.
2. The generation of new genes in higher primates and human genomes uses the database of human genome to search for the newly generated gene copies (i.e. the ones with low diversity) in human genome by using the method of bioinformatics. Through the analysis of representative primate species, the generation age of new genes is determined to find out the unique new genes in great apes, especially in human beings To explore the patterns and functional consequences of new genes in primate evolution and human origin.
3. From the perspective of molecular structure and evolution, most animal toxins are encoded by species or group specific genes, so they also belong to the category of new genes. In cooperation with Dr. Zhang Yun, who studies animal toxins, and based on the above research on the origin and occurrence of new genes, we will study the formation rules of new genes of animal toxins, so as to provide some theoretical basis for the screening of new active drugs and even the synthesis.
4. The origin and evolution of mammalian sex chromosomes has established a unique model to study the origin and evolution of mammalian sex chromosomes.
Academic achievements
We have developed a system to study the origin and evolution of new genes. Through systematic search, we have identified dozens of young genes, including Monkey King gene published recently and Sphinx gene, the first young RNA gene discovered so far. In the research named "Monkey King gene", it is the first time to clarify how gene division is realized. The gene family also tells us that the regulatory sequence of genes can be produced in a very short time. The discovery of Sphinx opened the first page of the study on the origin of many non protein coding RNA (ncRNA) genes in the genome. The further study of Sphinx and its chromosome 4 in Drosophila melanogaster has overturned a misconception in genetics that there is no exchange recombination. It is necessary to revise the relevant textbooks accordingly. It has been published in science, naturegenetics, PNAs, nature, naturereview genetics, genetics, molbioevolution, naturebeiotechnology, genome research, plantcell, plosgenetics, trends in genetics, genome biology, molecular biology and evolution, Chinese science, and science A number of papers have been published in a series of important academic journals, such as the Chinese Academy of Sciences bulletin.
Wang，W.etal.，2005OriginandEvolutio nofNewExonsinRodents.GenomeRes .（inpress）.
Peng Lixin, Zheng Hongkun, Li Xin, Yang Shuang, Chen Hong, Wang Wen, 2005, the origin and evolution of two new exons in zfp39, Science Bulletin (in print).
Lee，W.H.，Li，Y.，Lai，R.，Li，S.，Zhang，Y.，Wang，W.2005VarietyofAntimicrobialPeptidesintheBombinamaximaToadandEvidenceoftheir RapidDiversification.Euro .J.Immunol.35：1220-1229.
Yu，J.，Wang，J.，Lin，W.，Li，S.，Li，H.，… Wang，W.，etal.2005ThegenomeofOryzasativa：Ah istoryofDuplications.PLoSBiol .，3（2）：e38.
Wang，W.，asoneoftheauthorsintheSilkwormGenomeSequencingConsortium.2005Adraftsequenceforthegenomeofthedomesticatedsilkworm（Bombyxmori）。 Science306：1937-1940.
Li Xin, Yang Shuang, Peng Lixin, Chen Hong, Wang Wen, 2004 the origin and evolution of new genes. Scientific bulletin, 49:1219-1225
Wang，W.，Yu，H.，Long，M.2004Duplication-degenerationasamechanismofgenefissionandtheorigin ofDrosophilanewgenes.NatureGenetics ，36：523-527.
Wang，W.，Thornton，K.，Emer
Chinese PinYin : Wang Wen
Wang Wen
