Zhang Xianning

Zhang Xianning

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From December 1999 to August 2004, he worked in the laboratory of Biochemistry and molecular biology of Medical College of Ningbo University as associate professor, professor and director, part-time master supervisor of Shanghai Institute of life sciences, Chinese Academy of Sciences, young and middle-aged discipline leader of provincial universities, and the second level candidate of provincial 151 talents;

Personal experience

Born in February 1965 in Xianyang City, Shaanxi Province. In July 1986, he graduated from Biology Department of Qinghai Normal University with a bachelor's degree; in July 1993, he graduated from medical genetics of Shanghai Medical University with a master's degree; in July 1996, he graduated from genetics Department of Fudan University with a doctor's degree; in June 1998, he graduated from molecular neurobiology Department of Shanghai Medical University with a postdoctoral degree; from July 1998 to November 1999, he worked in genetics Department of Fudan University Cheng, associate professor, State Key Laboratory; Professor, Department of medical genetics, School of medicine, Zhejiang University since September 2004. From August 2007 to October 2007, he studied medicine in UCLA Medical College. From January 2008 to March 2008, I visited Professor Douglas Wallace, director of the center for molecular and mitochondrial medicine and genetics (mammag) of the University of California Irvine (UCI) School of medicine and academician of the American Academy of Sciences. member of psychiatry genetics cooperative group of Medical Genetics Society of Chinese Medical Association, executive director of China eugenics Association. member of biology group of Medical Education Society of Chinese Medical Association, executive director of Zhejiang genetic society, leader of medical genetic professional committee, director of Zhejiang cell biology society, editorial board member of Chinese Journal of eugenics and genetics, science and technology award evaluation expert of Ministry of education, distinguished expert of Zhejiang international nanotechnology research and Development Center (National International Joint Research Center), and China Cell Biology Association Member, branch of medical cell biology, society of zoology.

Lecture course

Medical genetics, genomics medicine, clinical genetics, medical molecular genetics, medical cell biology, molecular immunology, evolutionary genetics, cell culture technology, human genetics and health, etc.

Research direction

Disease genomics.

Main contributions

He has successively presided over scientific research projects such as National Natural Science Foundation of China and Zhejiang Natural Science Foundation, and participated in several "863", "973", National Natural Science Foundation of China, Ministry of health, Ministry of education and Shanghai scientific research projects. There are many kinds of diseases, such as idiopathic lupus erythematosus (SMA), simple dyskinesia of the retina (ADHD), dyskinesia of the retina (SMA), dyskinesia of the retina (SMA), dyskinesia of the retina (SMA), dyskinesia of the retina (SMA), dyskinesia of the retina (SMA) and dyskinesia of the soleus (SD) 16 papers have been published in SCI and EI. he once undertook the project of China Postdoctoral Natural Science Foundation, and in recent years, he presided over scientific research projects including provincial natural science foundation, etc. So far, more than 50 papers have been published in many academic journals at home and abroad, such as genomics, American Journal of medical genetics, British Journal of pharmacology, Chinese medical journal, Chinese Journal of genetics, genetics, Chinese medical journal, Chinese Journal of medical genetics, etc. According to incomplete statistics, the paper has been cited more than 70 times by others in domestic and foreign academic journals (excluding self citation factor). the insertion / deletion mutation (indel) was first found in the highly conserved helix initiation motif of K9 in Chinese EPPK patients, which has been verified by the human gene mutation database (HGMD) And the human intermediate filament database (hifd) Included. One case of EPPK was successfully diagnosed as the first case in the world. According to incomplete statistics, papers and works have been cited more than 200 times by scholars at home and abroad, He is also the author of the monograph "Encyclopedia of molecular mechanisms of disease" (Springer Verlag, 2009), the monograph "Atlas of genetic diagnosis and counseling" (Humana press, 2006), the monograph "illustrative Dictionary of metabolic diseases" (Taylor & Francis, 2006) and the American scholar ro The serotonin, edited by thbl Receptors:FromMolecularPharmacologytoHumanTherapeutics 》(humanapress, 2006). He has won the second prize of Shanghai Science and Technology Progress Award and the third prize of Zhejiang science and technology award. He was selected as the young and middle-aged discipline (Genetics) leader in Zhejiang universities and the second level personnel of "new century 151 talent project" in Zhejiang Province. scientific research project 1. General project of National Natural Science Foundation of China: "construction of mouse model with indel mutation of KRT9 gene in epidermolysis palmoplantar keratosis by microinjection and gene knock in technology" (amount of funds: 330000 yuan; start and end: 2010.1-2012.12). 2. General project of science and technology plan of Zhejiang Province: "construction of early diagnosis platform for type I spinal muscular atrophy (SMA1)" (funding: 100000 yuan; start and end: April 2007 to December 2009). 3. General program of National Natural Science Foundation of China: "Research on preimplantation genetic diagnosis of epidermolytic palmoplantar keratosis (EPPK)" (amount of funds: 280000 yuan; start and end: 2007.1-2009.12). (4) Ningbo key doctor's Fund: "EPPK gene mutation spectrum and all trans retinoic acid treatment in Chinese" (funding: 100000 yuan; start and end: 2004.1-2005.12). 5. Medical and health research project of Zhejiang Province: "mapping of KRT9 gene mutation spectrum in Chinese patients with epidermolysis palmoplantar keratosis" (amount of funding: 10000 yuan; starting and ending date: July 2003 to December 2005). 6. Ningbo Agricultural and social development scientific research project: "establishment, application and research of modern molecular diagnostic technology" (funding: 40000 yuan; start and end: 2001.1-2003.12). 7. Ningbo doctor's Fund: "genetics of schizophrenia and gene cloning" (funding: 30000 yuan; start and end: 2001.1-2002.12). 8. Zhejiang Natural Science Foundation: "genetics of schizophrenia and gene cloning" (funding: 40000 yuan; start and end: 2001.1-2003.12). 9. Zhejiang medical and Health Research Fund: "the location of schizophrenia related genes in Chinese" (amount of funding: 20000 yuan; start and end: May 2000 to December 2003). 10. Scientific research project of Zhejiang Provincial Department of Education: "localization and cloning of schizophrenia related genes in Chinese" (funding: 15000 yuan; starting and ending date: 2000.7-2002.12). 11. China Postdoctoral Natural Science Foundation: "the role of arrestins in opioid receptor desensitization" (funding: 10000 yuan; start and end: 1996-1998). 12. Zhejiang new century higher education teaching reform project: "the establishment and practical research of new medical curriculum evaluation index system" (funding: 20000 yuan; starting and ending date: 2010.1-2011.12). Zhang Xianning, editor in chief. Thompson & Thompson genetics in medicine, 7th ed (Bilingual Edition), Peking University Medical Press, 2009. 2. Edited by Zuo Chen. Medical Genetics (5th Edition), people's Health Publishing House, 2008. (participated in the compilation). 3. Edited by Zuo Chen. Medical genetics learning guidance and exercise collection (2nd Edition), people's Health Publishing House, 2008. (participated in the compilation). Fu songbin, chief editor of Chen Feng. Learning guidance and exercise collection of Medical Biology (3rd Edition), people's Health Publishing House, 2008. (participated in the compilation). 5. Lu Guohui, edited by Xu Xiangmin. Clinical genetic counseling, Peking University Medical Press, 2007. (participated in the compilation). 6. Li Chengji, editor in chief, Zhang Xianning, deputy editor in chief. Medical Journal

Chinese PinYin : Zhang Xian Ning